Human Studies

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections.

Dauby N, Goetghebuer T, Kollmann TR, Levy J, Marchant A.
Lancet Infect Dis. 2012 Feb 23. [Epub ahead of print]

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Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.

Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt AM, Audibert F, Speert DP, Lacaze-Masmonteil T, Soudeyns H, Kollmann TR.
J Infect Dis. 2010 Dec 1;202(11):1754-63. Epub 2010 Oct 26.

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Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.

Corbett NP, Blimkie D, Ho KC, Cai B, Sutherland DP, Kallos A, Crabtree J, Rein-Weston A, Lavoie PM, Turvey SE, Hawkins NR, Self SG, Wilson CB, Hajjar AM, Fortuno ES 3rd, Kollmann TR.
PLoS One. 2010 Nov 30;5(11):e15041.

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Neonatal innate TLR-mediated responses are distinct from those of adults.

Kollmann TR, Crabtree J, Rein-Weston A, Blimkie D, Thommai F, Wang XY, Lavoie PM, Furlong J, Fortuno ES 3rd, Hajjar AM, Hawkins NR, Self SG, Wilson CB.
J Immunol. 2009 Dec 1;183(11):7150-60. Epub 2009 Nov 16.

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Vaccine and Adjuvant Development

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults.

Behzad H, Huckriede AL, Haynes L, Gentleman B, Coyle K, Wilschut JC, Kollmann TR, Reed SG, McElhaney JE.
J Infect Dis. 2012 Feb;205(3):466-73. Epub 2011 Dec 5.

pubmed A single immunization near birth elicits immediate and lifelong protective immunity.

Reikie BA, Smolen KK, Fortuno ES 3rd, Loeffler DI, Cai B, Blimkie D, Kollmann TR.
Vaccine. 2010 Dec 10;29(1):83-90. Epub 2010 Oct 27.

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Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting.

Smolen KK, Loeffler DI, Reikie BA, Aplin L, Cai B, Fortuno ES 3rd, Kollmann TR.
Vaccine. 2009 Dec 10;28(1):235-42. Epub 2009 Sep 29.

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Fine-tuning the safety and immunogenicity of Listeria monocytogenes-based neonatal vaccine platforms.

Loeffler DI, Smolen K, Aplin L, Cai B, Kollmann TR.
Vaccine. 2009 Feb 5;27(6):919-27. Epub 2008 Dec 4.

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Induction of protective immunity to Listeria monocytogenes in neonates.

Kollmann TR, Reikie B, Blimkie D, Way SS, Hajjar AM, Arispe K, Shaulov A, Wilson CB.
J Immunol. 2007 Mar 15;178(6):3695-701.

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Immunological Methods

Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria.

Shey MS, Hughes EJ, de Kock M, Barnard C, Stone L, Kollmann TR, Hanekom WA, Scriba TJ.
J Immunol Methods. 2012 Feb 28;376(1-2):79-88. Epub 2011 Dec 1.

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Flow cytometry data standards.

Spidlen J, Shooshtari P, Kollmann TR, Brinkman RR.
BMC Res Notes. 2011 Mar 7;4:50.

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Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.

Blimkie D, Fortuno ES 3rd, Yan H, Cho P, Ho K, Turvey SE, Marchant A, Goriely S, Kollmann TR.
J Immunol Methods. 2011 Mar 7;366(1-2):89-99. Epub 2011 Jan 28.

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Facilitating the analysis of immunological data with visual analytic techniques.

Shih DC, Ho KC, Melnick KM, Rensink RA, Kollmann TR, Fortuno ES 3rd.
J Vis Exp. 2011 Jan 2;(47). pii: 2397. doi: 10.3791/2397.

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Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity.

Shooshtari P, Fortuno ES 3rd, Blimkie D, Yu M, Gupta A, Kollmann TR, Brinkman RR.
Cytometry A. 2010 Sep;77(9):873-80.

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Identification of B cells through negative gating-An example of the MIFlowCyt standard applied.

Blimkie D, Fortuno ES 3rd, Thommai F, Xu L, Fernandes E, Crabtree J, Rein-Weston A, Jansen K, Brinkman RR, Kollmann TR.
Cytometry A. 2010 Jun;77(6):546-51.

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